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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '8ea58c480f0a88c24ed09527b06e4cd642d38eaff9fc6c54b8da61c1943fcb9a' 
  AND token = '75+DDXO39SrOjhxtbHDPfUUlOk4c8kzJkA7gMWPX4Eo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}