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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '89b33ed6552c09ccdc4149d397a75407f5286d09d0d3f8e70d3b5022d7f8bfec' 
  AND token = 'Ek3OtttHUWzPHbnyOry5+m1B6RFcVzW2e//01rPzdQo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}