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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5d80b83e111b0ee1b322dbb090d7f8fe4147fa462f04b74df8714cbaa220b5c9' 
  AND token = 'Yz6/6sh6siCZ34hYKoTmK6D5pUXm2l3rJyrF/dSX2XE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}