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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a78ce5ca3cb3d7e452b4e3690357654b3cf9a59e8c2ed49644274a1df8170db1' 
  AND token = 'NutFWAEhleoCVWfEgvEXXaHQRZ1GVwkk2b4ks4XOSpM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}