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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e4535e99f46a4093b99e8e9752b63573b130752de38686e21d0d2208d341b3e7' 
  AND token = 'nwuv0b718hGjbjle5CRXLVgWT4PYcsPgiiF9MIJ+SlM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}