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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '0d450a77a7c65fb07695001429a185c4e35bdd2570c8111307a042429b795ae3' 
  AND token = 'ZCfULJME9L1s+f2iJgsfZawXF7FAGPEC66KtMQAnyN8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}