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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2ef0eadb9a48ab6a131b1fb333c9b625e9e1fb78749d207f0550802dba858b28' 
  AND token = 'nK+wj2Rkt+yoRQ9Hv+BY20QA0UapZhIAd1dvKk8I/fU=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}