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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '729ee0f49e08fdb184e7ab364ad308c260f9be3f43f88c4a5e37f370339435de' 
  AND token = 'L281F+RM5b5C953Mvl/x7Ur8wMXdA+ZHWBd+USjb2Gg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}