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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '14afd226cdc258be18024ef20c0f43dbadc71c905fb7fdfefd388e343c0dc322' 
  AND token = 'V/ooDPhp1IsMLYJ4Iqq4cqqcT6Qs+Q7eAdLaANlj1C8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}