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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '48458ad1090bc44bb7efce18d96d9b0090f3b56aaf30c00bab1e644b1f181900' 
  AND token = 'zxpnvfc/Z8mgpPLQXOAq1NWAhpzERvyuvpNZkwoOt2g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00031

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}