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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '73e6fa798eee8f0fb75a21a0540cae968d56e10e6902f74b1e143019946f5d3e' 
  AND token = 'Qc4KT3QqdyjnZz1/6DPiv8cntMOKdK0VFR8D4b6DiU4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}