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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f8b39f79eb50019f5a5a6883b04ba7c80f0f8a6654ce46cebd27c409a58959d1' 
  AND token = 'qIDX40Gyg5pHPDvaBpdfT6dGDBrQY+qxzqGuJcpG8dY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}