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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6edf18977c37f280adcbd0a8928d231d568c103f29b2b0a3e8e03e1b29c0aa04' 
  AND token = 'tOzZPtH/uKWBUJv3xtpT5UB8IoCBnOMHuE3OlpeM1k8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00016

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}