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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4333689b19934b88884afb76bc9801b3b42bb9799cf643b91923e6cbbd2c2078' 
  AND token = 'T4Zt+XObCMSrzo04j2M2VFQW3z8WuZ+1CsPLPxhliUg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}