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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '845046a218802ad88857d3f95b9aeb9e0e5aef55c2c9aacd1369ebbcebf0736e' 
  AND token = 'fkomnPTIo0cYdxkbPgKaoxVaTcc8pRtIDOzDlmnbjzw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}