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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '645bb244c71c1d87d819b52ffe84f97a9ab7bbf697637b05ecad09ac6ec3b7d4' 
  AND token = 'R4CEpb5D3k4WqyeIUtejaWT5zXfjtv6oPyb1ckxhMIs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}