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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b6bcc414e7504b815c445c43c44b0d5dc95eef150d1b789298f0feb44fefb49' 
  AND token = 'TlpRRrXPc5H5vlQf9m+0hRr85DoadLwMzhFERZTCdss=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}