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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '7043de09e98181e7d7d73e7c758df42f250563baefb997ec5fa2f49caab561e9' 
  AND token = '+V/m666QSlimC8dAa40t2599lxnjoki5WblLGWc0HN0=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}