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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '03353d7d23e0becbb9964e0e1f213dc2754d7de4b1090e93425f8c566ddd6d00' 
  AND token = 'uJFi/YIIE1e/XEY4fbTXc8GJhNif9s7N7XtoMjLqsKY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00028

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}