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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4bc21eade321b44c06b451e2e79855f217267a6e0fba388ada11f3cabbb54abb' 
  AND token = 'ILoWOgqF+SGeKmeAXfMakDvui9EZHabkgPp1RGUM/r8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}