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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'f10bd916710d24dc946e6266e882820e1f4ff31d6f642dfedc329e35fa3d4f97' 
  AND token = '4Qjnc4o+i6vkeoPGbrz2cgosXz3CQvj4yNIwVn/tBJI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}