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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a43ad9f3861d8e0fd97268a45d4c1270bb12922a6c05aff0d7d304071246210d' 
  AND token = '7hcjC8rmTjcrk5SAGNVwybOwkYatwnviTCh+LUBudEE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}