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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'a80c493fd4530bf4b5100c3d37b310e08a1a2be5414c148e3aae98ee30c9f281' 
  AND token = 'CgBMK9wZAT5DgpRbaYeZjewVxeDnncBBsVV462D7mmk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}