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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '12e0507a343be3b11d7377ae5a9a8a1b9ec5ddd40606832463ccbe41263a123d' 
  AND token = 'vxKERNths05/09k/E8lhzm0mPhFR2I2mE71xMpPcSOM=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00023

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}