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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'e9323b7d111a04fe72646031131c3d7d35eb40c05d4c9890e562c6d18c3d6b25' 
  AND token = 'VRA0wWJVDIQYDqIWAWi97Md+F94wZ4KncYAg0yslUQg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00026

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}