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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '53e355b82d4b4063169d10b270e2e23e1bc0a99b6c07021b02e50a55db1cc0b2' 
  AND token = 'A9x+2rdClX368NdLqnlp7llNWj8FaqTBGSbbf/tE834=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}