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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '78bc382669c89abe7d88afe22df49e97992fb2e8b010c4981bb0eaebfe152e8d' 
  AND token = 'FvgP2UcvP28K2TzPUy4CLYfICTcySn7x1FW81V+4TLQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}