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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b3aa65ca2bc030c95cbaaf4b97f500fc222fed430bd3b4885516ff63d72d80f' 
  AND token = '/nhy06mtD0z90XRz+3mdrNnS2IDVydvZJnFn+KOn88Y=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}