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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '45333747d13e4490cc3702a4b10dd9f30b7ab84ad2bbddbe63c3c668c23601ff' 
  AND token = 'J/P0ZRMoGCe0xIevK9LISLDHs2fGL408a/t9KsU0/k4=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}