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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'af37094b108b4e57f9442997f8878198994b55188059b0d73398f66cb98440a9' 
  AND token = 'XenqGC1XiVQhSxZskDLmLP3jVEf/1VB8g9BxkrnaPs8=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}