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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '72cd36cfee3f406494356852222fc7b80b43450464164e8531defb9cdfbe3e96' 
  AND token = 'iS+2ZA5ujypkfON71FKZXP4QkFa4mVQ9FcW9bWvkfoA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}