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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4b287a01fb0b05381c7847cf76468f24863339019f6c5f312e01b6a0b4e15293' 
  AND token = '/4Z1TkeOhlYqMLfHgkDM7fT/acwT/tpKNzWmbqrz4KE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}