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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'b0c63a5ad81408ce329c2879f97bffe66637d3f1c29715cbd3fb67eabe8c954d' 
  AND token = 'eVHzUT9Tle7UJtG/QdhB0+Bxvfb2/LUrho1i2N4L/Vk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}