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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4421f5d06a016f18932116a5189d6307cb17db86285a854c73aa99960ee5ebca' 
  AND token = '1RIJMAEVXFSF9POFjoqrN+5tx1NjMbRhVrm4vhhdYjk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}