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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '228cb330eb307f67b9995c7242a433e72a00c39c8fde7d59904826767b2d433f' 
  AND token = 'JsMqt9ZaCRmDE7X4z3e28ecoK1OewkPcpkRQ0yqutlI=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00021

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}