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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '220a0a93d588791c671279df5d5c2c17d3db96cf91cb609e8786fdeb241ca018' 
  AND token = 'EQt4oeVkcaxih979CVOqxzvEDy9yo6AltNmafSFpaZo=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}