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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2228d613757a23eb0ec3d7acc1f23724cd8767e6b49c2d459433c4f253247d64' 
  AND token = '4DROop+sUFJMSiSr4NrX9JLicHfPAsBIAynBhvvS02g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}