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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4605926fc03a957068f25b9e9cb9e39a3fe3a22c987be1f0a64232368f21d621' 
  AND token = 'N2d5ta55KzTh7IkJhHmMHISm5NDuEjzEyqPX3825jIQ=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}