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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '4441141efe700722e285cfec72a99dd83df4f979e214a02ae9b2cae55e6fb4a4' 
  AND token = 'ayElBEMP6YeYI7dugY//8mCF+QeIHMBI0oxN8HEyv2w=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00015

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}