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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'ac43461ff4fc7760199748087378edc79f9839c4213477155644e7b3b2e009b1' 
  AND token = '1Ez+/JAP1nvPIoLeEdzWB4eJcNQUmRu32jA/GZCQ99g=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}