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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2db3ed688c0e799d3e34e022b2020dcb75dd33ac7c8391f145a041693b6da1f8' 
  AND token = 'eEDnS4gGKRPH9d21sXHHVVxtQdgMZhE2yJLl9vkA/8A=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}