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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '01c4e8799eab2693299adddf68c7121411ecb25df5b389eec48227001d170342' 
  AND token = '18sdQwCiPGcH/VEIVmwRrqz/5DvKrzsRAfxuUDV57fs=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00030

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}