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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '443636bd39a2aa101bafd0234c9a3fbaf9525f9bfa38cd781b08cd09cf55e643' 
  AND token = 'fv+RKaqBnFJ5avs9K2c0EarRo4dNxUd0demHUudtuJE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}