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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '745a009c871469f3c96bc0179a35780ba80786ae10e8a79195b3d33c9dfe18e8' 
  AND token = 'ujXHSw+l9LNR8tOg94jeC3deJsyANCn6NXOGZLUGyRg=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00020

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}