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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '5ad66240cae73510b7486e6e4d41e52dd9c133d18aa6e778fe2e6f19f8bd67da' 
  AND token = 'D94lQ2Vj/3avDIk8dVVUmqKAuwlwDeqAJc2eVl+9vuk=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}