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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = 'd6641468067ca216bb9983a0bb8cee4a938281feca90d2fca9b9c5a6b5293671' 
  AND token = 'ioTX7/eZG7xsyPTr2rXN+SWKoQvIUnA0xdwed9yZjOE=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}