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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '75707f46cf33bb6a220b18fdf11345e0adcbff447ad2144a7e38406f8f20c436' 
  AND token = 'N4oTHr+X6A75ZA3kFn6lcdp8D8zumFnAbNH7FuyNk7U=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00019

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}