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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '249358a87b5e77cc61df053e38488d3a416d1cb1c51aa6d1b0d1a5df15025b25' 
  AND token = 'Ga7PdAD0CoenuqUlCF/lkVXY1yoFGmrDCOF1+8gEWkw=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00018

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}