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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '2e2a3053965a6f9a2bc2ea5efc6ad00c378fc4b7cb51bd4926a32cd48811e522' 
  AND token = 'sqZPnG0Bl2b5w7oieB3KUXofV+AK03VT6cDeGmSMfsY=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00017

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}