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SELECT 
  1 
FROM 
  cscart_lock_keys 
WHERE 
  key_id = '6ca456bbf79d77aa93c3b8e9f966fdf71ec87ba623f91589440d288e72b27fb0' 
  AND token = 'DKfw8I40x7ceFoCvXOvrcIa6Gz11bYV8CcfKsrN7abA=' 
  AND expiry_at > UNIX_TIMESTAMP(NOW())

Query time 0.00025

JSON explain

{
  "query_block": {
    "select_id": 1,
    "message": "no matching row in const table"
  }
}